Scale-up of fluidized bed drying: Impact of process and …
Schematics of a) MiniGlatt and b) Glatt GCPG-1 fluidized bed dryers. Several diagnostic devices were used to measure the bed temperature, the exhaust air temperature, and humidity continuously throughout the process. The bed temperature was measured using a K-type thermocouple (OMEGA MWTC, Omega Inc.). The exhaust air …
Liquids
GFC 16 – Continuous fluidized bed coating on pilot scale June 7, 2024 - 9:48 am; Glatt Colloquium on Powder Technologies. 2024. Weimar. Germany June 6, 2024 - 8:46 am; Glatt at ACHEMA 2024. Hall 3.0 …
Development and optimization of multiparticulate drug …
In the present study, a multiple unit floating drug delivery system (FDDS) based on gas formation technique has been developed in which microcrystalline cellulose (MCC) pellets (Celphere ®, CP 507) were coated with alfuzosin HCl on fluidized bed processor (Pam Glatt, Glatt , Germany) by employing bottom spray technique.
Vasudev Bhil presentations | SlideShare
Specialties: -troubleshooting & technology transfer. Knowledge of Technology: - Pelletization, (Bottom spray), Granulation using Top Spray and RMG, Compression, Coating, Capsule filling and packaging with IPQC. -Instrument handling:- Wurster Coater (Fluidized Bed Processor) such as Pam Glatt, Rapid Mixer Granulator, C...
Contract manufacturing by fluid bed and spouted bed …
Glatt's patented spouted bed technology is – like the fluid bed technology – also based on the basic principle of fluidizing particles by agitating them with upward flowing process air. Key differences are the design of the process air inlet and the extended process chamber; this creates particularly gentle conditions that are ideal for ...
CFD simulations for prediction of scaling effects in …
To study the scale up effects in fluidized bed processors, particles were loaded in three fluidized bed processors of different scales. The Vector Lab Micro was operated with 150 g of solids, the Glatt GPCG-1 was operated with 2 kg of solids, and the Niro MP4 was operated with 45 kg of solids.The three fluidized bed processors and …
FLUIDIZED BED SYSTEMS
The Glatt company and the fluid bed. The Glatt Corporation and fluid bed technology have become synonymous. Our heart beats for the fluid bed. For this reason, Glatt has had a decisive influence on the development and spread of fluid bed technology throughout the world over the past decades. Today, Glatt employs more than 3,000 people in more than
How to Optimize Fluid Bed Processing Technology
The fluid bed agglomeration process is a combination of three steps, namely, dry mixing, spray agglomeration, and drying to a desired moisture level. Granule size is directly proportional to the bed humidity during granulation; hence, control of this humidity during scale-up is essential. Select Chapter 12 - Integrated Systems.
CFD simulations for prediction of scaling effects in …
To study the scale up effects in !uidized bed processors, particles were loaded in three !uidized bed processors of different scales. The Vector Lab Micro was operated with 150 g of solids, the Glatt GPCG-1 was operatedwith 2 kg of solids, and the Niro MP4 was oper-ated with 45 kg of solids. The three !uidized bed processors and di-
Fluid Bed Processor (FBP)
Fluid bed processor is widely used for drying applications. By passing heated air through the fluidized bed, moisture is rapidly evaporated from the particles, leading to efficient and uniform drying. Granulation: Granulation involves the agglomeration of fine particles into larger, more uniform granules.
(PDF) CFD simulations for prediction of scaling effects in
Other relevant work and newer technologies Parker et al. looked at three fluidized bed processors of varying scales (Vector Lab Micro of 150 g operational scale, Glatt CPCG-1 of 2kg operational ...
Fluidized Bed Dryer : Parts, Working Principle and …
Fluidized bed dryer (fluidized bed dryer) achieves faster drying rates with the drying time ranging from 20 minutes to 40 minutes. With the material in a fluidized state, there are no hot spots. It enhances …
Understanding and Predicting Bed humidity in Fluidized Bed …
Bed humidity is a critical parameter that needs to be controlled in a fluidized bed granulation to ensure reliability. To predict and control the bed humidity during the fluidized bed granulation process, a simple model based on the mass conservation of moisture was developed. The moisture mass balance model quantitatively simulates the effects of …
Process Development, Optimization, and Scale-up: Fluid-bed …
A typical fluid-bed wet granulation sequence consists of dry blending, wet granulation, and drying steps. Raw materials are first fluidized by hot inlet air for blending. Granulation fluid is then sprayed onto the pre-blended material, until the desired moisture content or granule size is achieved.
Safety concept for fluid bed and spouted bed systems
Design explosion protection is one of the most important precautionary measures for operating fluidized bed and spouted bed systems in a process-safe manner. Atex-compliant designs range from explosion-suppressed to explosion-pressure-resistant apparatus. When liquids are spray granulated, powders agglomerated or particles …
Scaling up of the fluidized bed granulation process
The scaling up is based on the relative droplet size, and the powder bed moisture content at the end of the spraying cycle. The present study describes the scaling up of the fluidized granulation process from small (5 kg scale) to medium (30 kg scale) and to production fluid bed scale (120 kg scale). The granulation process is scaled up with as ...
Fluid Bed Technology: Overview and Parameters for …
Top Spray Fluid Bed Process Top-spraying is the most well known process for wet granulation, and it has been used in various industries for more than 30 years. A top-spray processor has three components (Fig. 2). An air-handling system, which can be equipped with humidification or de-humidification and dew-point control.
Fluid Bed Processing of Pharmaceuticals
The product is discharged at a controlled rate to maintain an optimum bed height. Special features include easy scale-up and a small footprint. PRECISION-COATER: this multi-functional fluid bed processor can be used to make pellets by layering the active material onto an inert core. Offering high spray rates for short processes, non-pareil ...
Pharmaceutical Fluid Bed R&D Processing
STREA-1 Classic. Lab Scale Fluid Bed Processor 0.8-4 litresThe STREA-1 Classic is the flexible choice when taking the first steps towards process optimisation. The STREA-1 is ATEX certified and suitable for use with organic solvents (explosion group IIA). It is designed for processing of fine powders, pellets, granules, crystals, and mini tablets.
A Definitive Guide to Fluid Bed Granulation Process …
Now that you know what happens when a stream of gas flows into the bed, let me now focus on the fluidized granulator principle of operation. Generally, the fluid bed granulation process involves three critical stages: Using a stream of air to fluidize the bed. Adding a granulation fluid to agglomerate the particles.
VALIDATION OF FLUIDIZED BED PROCESSOR (MINI …
A fluid bed system brings powdery or grained substances (bulk material) in a floating condition, with the carrying air flow enabled to exchange heat and substances with the floating material. Fluidizes bed processor (Mini Glatt), a component laboratory device uses the above principle and the equipment is designed to perform drying, granulation
Fluid Bed Processing Technology | SpringerLink
Abstract. Fluid bed processing technology is widely used in the pharmaceutical industry for the processing of multiparticulates. The chapter describes the theory of fluidization followed by the components of a fluidized bed processor and their functioning. Further, the formulation, process and equipment-related factors that affect product ...
Fluid Bed Coater, Processor, Granulation, FBC Wurster Coating machine
Fluid bed coating machine. Shree Bhagwati. Fluid bed granulator also called fluidized bed granulator, fluid bed granulation process can integrate top spray for granulation and drying in one unit for fluid bed processing. Shree Bhagwati fluidized bed granulator machine have a modular design, the equipments are custom designed as 2 bar explosion ...
Tangential Process for granulation and coating by fluidized bed …
Tangential Spray process - This video animation shows the new multi-purpose approach to innovative fluidized bed processing. Tangential Process for granulation and coating by …
Fluidized Bed Granulation: A Promising Technique
Principle of fluidized bed processor: 8,10,27 The fluid bed it is the bed of powder material or solid particle bed. The hot air passed at high pressure through the air distribution plate which is place in bottom then particles are lifted from bottom and suspended in air stream this process known as fluidization process. ...
PHARMACEUTICAL VALIDATION OF FLUIDIZED …
A fluid bed system brings powdery or grained substances (bulk material) in a floating condition, with the carrying air flow enabled to exchange heat and substances with the floating material. Fluidizes bed …
CFD analysis of air distribution in fluidised bed equipment
Depypere et al. [18] analyzed the uniformity of air distribution inside the plenum chamber of a laboratory-scale Glatt GPCG-1 type fluidized bed-coating unit. CFD simulations revealed that the ...
Fluid Bed Processor at Best Price in India
83% Response Rate. View Mobile Number. Contact Supplier Request a quote. Fluid Bed Processor Granulator, Steam ₹ 55,00,000. Get Quote. Fluid Bed Processor For Pharma Industry ₹ 45,00,000. Get Quote. …
Continuous wet granulation using fluidized-bed …
Glatt Continuous Fluidized-Bed Granulator (Glatt granulator)This machine also has two horizontal chambers, the inlet-air chamber (8) and the reaction chamber (5) (Fig. 2). The inlet-air chamber is divided by three vertical walls into four zones, in each of which the temperature and air volumetric flow rate is separately controllable. The major ...
REVIEW ON FLUIDIZED BED PROCESSOR TOOLS, …
The fluidized bed processor (FBP) isz a key technology used in pharmaceutical manufacturing today. Fluidized bed systems initially were used as a straight forward but very efficient dryer, but with the addition of a spray nozzle, they promptly transformed into granulators. The main concept of an Fluidized Bed Process or granulation